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Nucleic Acids Research, 1983, Vol. 11, No. 15 5267-5275
© 1983

MOLECULAR BIOLOGY

The N-ras oncogene assigned to the short arm of human chromosome 1

Bérengère de Martinville*, James M. Cunningham+, Mark J. Murray+,§ and Uta Francke*

*Department of Human Genetics, Yale University School of Medicine 333 Cedar Street, New Haven, CT 06510 +Center for Cancer Research, Massachussets Institute of Technology Cambridge, MA 02139, USA

Received June 7, 1983. Accepted July 1, 1983.

The human N-ras oncogene, Isolated from the HL-60 promyelocytic leukemia cell line, Is distantly related to viral oncogenes of Kirsten and Harvey sarcoma viruses. We have determined its chromosomal location by Southern blot analysis of DNAs from 37 human x rodent hybrid cell lines derived from 8 different human donors, some of whom carried balanced rearrangements of chromosome 1. The results indicate that the N-ras oncogene (RASN) is localized on the proximal part of the short arm of human chromosome 1, in region p3200<-cen.

§Present address: Zymos corporation,2121 N. 35th Street, Seattle, WA 98103, USA.


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