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Nucleic Acids Research, 1983, Vol. 11, No. 16 5381-5389
© 1983

MOLECULAR BIOLOGY

Nucleotide sequence of the constant region of a chicken µ heavy chain immonoglobulin mRNA

Auriel Dahan+, Claude-Agnès Reynaud+ and Jean-Claude Weill+,*

+Laboratoire d'lmmunodifférenciation, Institut Jacques Monod, CNRS Université Paris VII, Tour 43, 2 Place Jussieu, 75251 Paris, Cedex 05 *Institut d'lmmunobiologie, INSERM U20 and CNRS LA 143, Hopital Broussais 96, Rue Didot, 75674 Paris Cedex, France

Received June 21, 1983. Accepted July 22, 1983.

We have recently reported the sequence of a chicken Ig {lambda} light chain cDNA clone, isolated from a spleen partial cDNA library (1).In this paper, we describe the characterization of a cDNA clone coding for the chicken constant (C) region of the secreted µ chain. This is the first report on the nucleotide and amino acid sequence of a chicken Ig heavy chain constant region. It contains the 3' untranslated region of the µ mRNA up to the poly(A) tail, and, in comparison with the mouse Cy sequence, displays the overall domain size and organization of a secreted µ chain, i.e. : a characteristic COOH-terminal region, a Cnµ4, a Cµ3, a Cµ2, and part of a Cyl domain. The sequence homology between these two species ranges from 45 % for the Cµ4 to 18% for the Cy2. Thus, the Cy sequence appears much less conserved between chicken and mouse than their respective light chain constant regions (1). These results, together with some distinctive features of the Cµ2 domain, may be of evolutionary relevance and will be further discussed.


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