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Nucleic Acids Research, 1983, Vol. 11, No. 16 5569-5587
© 1983

MOLECULAR BIOLOGY

Homology maps of the Drosophila {alpha}-tubulin gene family: one of the four genes is different

Howard J. Baum, Yehudah Livneh* and Pieter C. Wensink

Department of Biochemistry and Rosenstiel Center, Brandeis University Waltham, MA 02254, USA

*Current address: Biotechnology General Ltd., Kiryat Weitzmann, Rehovot, Israel

Received March 18, 1983. Accepted July 22, 1983.

We describe the intron-exon structure of and the homology among the four {alpha}-tubulin genes of Drosophila melanogaster. Three of the genes share a highly conserved 1.3 kb sequence which corresponds to most of the RNA complementary portion of the genes. The fourth gene is different. Its 5' half has weak homology and its 3' half has moderate homology to the other three genes. The homology maps were first determined by electron microscopy of heteroduplexes between pairs of genes. Higher resolution maps were then obtained by gel analysis of heteroduplexes that had been digested with SI nuclease.


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