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Nucleic Acids Research, 1983, Vol. 11, No. 16 5621-5628
© 1983

MOLECULAR BIOLOGY

The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues

P.A. Cload and D.W. Hutchinson*

Department of Chemistry and Molecular Sciences, University of Warwick Coventry CV4 7AL, UK

*To whom correspondence should be addressed

Received July 7, 1983. Accepted July 27, 1983.

Substituted methylene diphosphonates are effective inhibitors of the RNA polymerase of influenza A virus causing 50% inhibition of the polymerase activity when they are present in the concentration range 10–85 µM. The inhibitory power of the methylene diphosphonates appears to be related to their ability to chelate with metal ions.


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