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Nucleic Acids Research, 1983, Vol. 11, No. 16 5629-5643
© 1983

MOLECULAR BIOLOGY

The nucleotide sequence of poliovirus type 3 leon 12 a1b: comparison with poliovirus type 1

Glyn Stanway, Alan J. Cann, Rudolf Hauptmann*, Pamela Hughes, Lindsay D. Clarke, Roger C. Mountford, Philip D. Minor1, Geoffrey C. Schild1 and Jeffrey W. Almond

Department of Microbiology, University of Leicester Leicester LEI 7RH 1National Institute for Biological Standards and Control Holly Hill, Hampstead, London NW3 6RB, UK

*Present address: Ernst-Boehringer-Institut fOr Arzneimittdforschung, Bender and Co. Ges mbH Wien, E r. Boehringer-Gasse 5-11, A-1121 Wien, Austria

Received July 5, 1983. Accepted July 19, 1983.

The complete nucleotide sequence of the genome of the Sabin vaccine strain of poliovirus type 3 (P3/Leon 12 a1 b) has been determined from cDNA cloned in E. coli. The genome comprises a 51 non-coding region of 742 nucleotides, a large open reading frame of 6618 nucleotides (89% of the sequence) and a 3' non-coding region of 72 nucleotides. There is 77.4% base-sequence homology and 89.6% predicted amino-acid homology between types 1 and 3. Conservation of all glutamine-glycine and tyrosine-glycine cleavage sites suggests a mechanism of polyprotein processing similar to that established for poliovirus type 1.


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