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Nucleic Acids Research, 1983, Vol. 11, No. 18 6331-6339
© 1983

MOLECULAR BIOLOGY

Chromosomal localization of the human c-fms oncogene

John Groffen1, Nora Heisterkamp1, Nigel Spurr2, Sharon Dana3, John J Wasmuth3 and John R Stephenson1

1Lab. Viral Cardnogenesis, National Cancer Institute-FCRF Frederick, MD 21701, USA 2Imperial Cancer Research Fund P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK 3Dept. Biological Chemistry, California College of Medicine, Univ. California Irvine, CA 92717, USA

Received June 27, 1983. Revised August 10, 1983. Accepted August 10, 1983.

A molecular probe was prepared with specificity for the human cellular homologue of transforming sequences represented within the McDonough strain of feline sarcoma virus (v-fms). By analysis of a series of mouse-human somatic cell hybrids containing variable complements of human chromosomes it was possible to assign this human oncogene, designated c-fms, to chromaome 5. Regional localization of c-fms to band q34 on chromosome 5 was accomplished by analysis of Chinese hamster-human cell hybrids containing as their only human components, terminal and interstitial deleted forms of chromosome 5. The localization of c-fms to chromosome 5 (q34) is of interest in view of reports of a specific, apparently interstitial, deletion involving approximately two thirds of the q arm of chromosome 5 in acute myelogenous leukemia cells.


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