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Nucleic Acids Research, 1983, Vol. 11, No. 2 477-488
© 1983

CHEMISTRY

Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method1

Yoshimasa Ike, Satoshi Ikuta, Moriyuki Sato, Ting Huang and Keiichi Itakura

Department of Molecular Genetics, City of Hope Research Institute Duarte, CA 91010, USA

Received November 16, 1982. Accepted December 20, 1982.

A solid phase method for the simultaneous synthesis of mixed oligonucleotides using a phosphotriester approach has been developed. For this synthesis, a mixture of mono or dimeric coupling units is used, and a slight difference in the reactivity of those units is found. However, this difference does not hamper the simultaneous, mixed oligonucleotide synthesis, and the sequence analysis of a product demonstrates the existence of a11 desired sequences in the final mixture.


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