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Nucleic Acids Research, 1983, Vol. 11, No. 21 7471-7485
© 1983

MOLECULAR BIOLOGY

Nucleotide sequences of Immunoglobulin µ heavy chain deletion mutants

W.O.T. Baczynsky1,2, Shunji Sugii2,3, Helios Murialdo4, Nancy Pennell1,2, Catherine Filkin1,2, Nobumichi Hozumi2,3 and Marc J. Shulman1,2,*

1Rheumatic Disease Unit, Wdlesley Hospital Toronto, Ont., M4Y 1J3 2Dept. Medical Biophysics, University of Toronto 3Ontario Cancer Institute 500 Sherbourne St., Toronto, Ont., M4X 1K9 4Dept. Medical Genetics, University of Toronto Toronto, Ont., M5S 1A8, Canada

*To whom correspondence shhould be addressed

Received June 30, 1983. Revised October 10, 1983. Accepted October 10, 1983.

Mutants of an IgM producing hybridoma cell line were isolated which produce n heavy chain fragments. Two such mutants were found to have internal deletions in the p gene and the nucleotide sequence of the deletion endpoints was determined. No evidence was found for a role of the heavy chain switch region in the formation of these deletions. The implications of these mutants in defining the requirements of immunoglobulin gene expression are discussed.


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