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Nucleic Acids Research, 1983, Vol. 11, No. 21 7505-7515
© 1983

MOLECULAR BIOLOGY

Selective lnactivatlon of the 3' to 5' exonndease activity of Escherichia coli DNA polymerase I by beat

Ph.J. Lecomte1 and O.P. Doubleday2

Laboratoire de Biophysique et Radiobiologie, Universite Libre de Bruxelles 67 rue des Chevaux, 1640 Rhode-St-Genese, Belgium

1Present address: Institut Jacques Monod, CNRS, Tour 43, 2 Place Jussieu, 75251 Paris, France

2Present address: MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton BNI 9QG, UK

Received October 5, 1983. Revised October 14, 1983. Accepted October 14, 1983.

Heat selectively inactivates the 3' to 5' exonuclease activity of E. coli DNA polymerase I, resulting in reduced dNTP turnover and lower fidelity of replication of homopolymer and natural DNA templates.


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