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Nucleic Acids Research, 1983, Vol. 11, No. 21 7595-7610
© 1983

MOLECULAR BIOLOGY

A second major class of Alu family repeated DNA sequences in a primate genome

Gary R. Daniels and Prescott L. Deininger

Department of Biochemistry, Louisiana State University Medical Center 1901 Perdido Street, New Orleans, LA 70112, USA

Received August 3, 1983. Revised October 5, 1983. Accepted October 5, 1983.

We have analyzed repetitive raft sequences in a prosimian. Gal ago crassicaudatus, and found that there are two distinct, highly repetitive families of sequences related to the human Alu family. The Type I family is closely analogous to the human Alu Family. The Type II family of repeats, which appears to be present in higher ccpy number, has a right half that is almost identical to the Type I family. However, the left half of the Type II sequence shows only limited hcmology to the galago Type I or human Alu families. A comparison of homologous sequences in the left half indicated that they are centered in regions of the Alu family which function as RNA polymsrase III promoters. We have also observed at least one example of a Type II left half that was integrated into the genome independent of the Alu family right half sequence. The Type II family appears to be of nuoh more recent evolutionary origin than the Type I and may have arisen by the independent integration of a BJR polymarase III pranoter adjacent to the right half of a Type I Alu family sequence.


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