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Nucleic Acids Research, 1983, Vol. 11, No. 22 7927-7945
© 1983

MOLECULAR BIOLOGY

Influence of DNA synthesis inhibition on the coordinate expression of core human hlstone genes during S phase

M. Plumb*, J. Stein+ and G. Stein*

*Department of Biochemistry and Molecular Biology Gainesville, FL 32610, USA +Department of Immunology and Medical Microbiology, University of Florida College of Medicine Gainesville, FL 32610, USA

Received July 18, 1983. Revised October 20, 1983. Accepted October 20, 1983.

Core hlstone mRNA metabolism has been examined 1n S phase HeLa cells recovering from UNA synthesis Inhibition by 1 mM hydroxyurea. Using cloned human hlstone genes as probes for hlstone mRNA quantitation, the response to and recovery from DNA synthesis Inhibition 1s shown to depend on the position of the cell with respect to the initiation of DNA replication. The incorporation of 3H-uridine Into multiple hlstone mRNAs in recovering cells does not exceed preinhibition levels, and as this Incorporation 1s maximal 1n early S phase, the synthesis of core hi stone mRNA is apparently related to the ordered replication of the genome. The total hlstone mRNA present in Interrupted S phase cells after recovery is not significantly different from that present in control cells, and a temporal and functional coupling between hi stone mRNA levels and the relative rate of DNA synthesis 1s maintained 1n perturbed cells.


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