Skip Navigation

This Article
Right arrow Print PDF (3186K)
Right arrow A corrigendum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (82)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by McBride, O.W.
Right arrow Articles by Aaronson, S.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McBride, O.W.
Right arrow Articles by Aaronson, S.A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1983, Vol. 11, No. 23 8221-8236
© 1983

MOLECULAR BIOLOGY

Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells

O.W. McBride*, D.C. Swan+, S.R. Tronick+, R. Gol+, D. Klimanis+, D.E. Moore* and S.A. Aaronson+

*Laboratories of Biochemistry, National Cancer Institute, National Institutes of Health Bethesda, MD 20205, USA +Laboratories of Cellular and Molecular Biology, National Institutes of Health Bethesda, MD 20205, USA

Received October 16, 1983. Accepted November 1, 1983.

The identification of transforming genes in human tumor cells has been made possible by DNA mediated gene transfer techniques. To date, it has been possible to show that most of these transforming genes are activated cellular analogues of the ras oncogene family. To better understand the relationship between these oncogenes and other human genes, we have determined their chromosomal localization by analyzing human rodent somatic cell hybrids with molecularly cloned human proto-oncogene probes. It was possible to assign N-ras to chromosome 1 and regionally localize c-K-ras-1 and c-K-ras-2 to human chromosomes 6pter-ql3 and 12q, respectively. These results nlong with previous studies demonstrate the highly dispersed nature of ras genes in the human genome. Previous reports indicated that the c-myb gene also resides on chromosome 6. It has been possible to sublocalize c-myb to the long arm ol chromosome 6 (q15–q21). The non-random aberrations in chromosomes 1, 6 and 12 that occur in certain human tumors suggest possible etiologlc involvement of ras and/or myb oncogenes in such tumors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.