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Nucleic Acids Research, 1983, Vol. 11, No. 23 8303-8315
© 1983

MOLECULAR BIOLOGY

c-myc gene rearrangements involving gamma immunoglobulin heavy chain gene switch regions in murine plasmacytomas

Linda J. Harris1,4, Elaine F. Remmers1, Peter Brodeur2, Roy Riblet2, Peter D'Eustachio3 and Kenneth B. Marcu1,*

1Biochemistry Department SUNY, Stony Brook, NY 11794 2Institute for Cancer Research 7701 Burholme Ave., Philadelphia, PA 19111 3Biochemistry Department, New York University Medical Center 550 First Avenue, New York, NY 10016, USA

*To whom reprint requests should be addressed

Received August 15, 1983. Revised November 8, 1983. Accepted November 8, 1983.

In murine plasmacytomas, the c-myc gene has frequently been found to undergo rearrangement by virtue of a T(12;15) chromosome translocation. The immunoglobulin heavy chain gene switch region (S{alpha}) constitutes the target for most of these recombinations particularly in IgA producing plasmacytanas. We sought to identify non-S{alpha} myc target sites in several IgG producing tumors. The c-myc target in MPC-11 (a BALB/c IgG2b producing plasmacytoma) has been cloned, localized to the Igh-C locus and Identified as the Y2a heavy chain gene switch region (S {gamma}2a). Furthermore, by Southern blot hybridization, we have determined that the S{gamma}2b region is the c-myc target in two NZB IgG2b producing plasmacytanas. The potential relation between Ig class expressed and c-myc translocation target is discussed.

4Present address: Genetic Systems Corporation, 3005 First Avenue, Seattle, WA 98121, USA


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