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Nucleic Acids Research, 1983, Vol. 11, No. 23 8461-8472
© 1983

MOLECULAR BIOLOGY

The cloned rRNA genes of P. lophurae: a novel rDNA structure

Thomas R. Unnasch and Dyann F. Wirth

Department of Tropical Public Health, Harvard School of Public Health Boston, MA 02115, USA

Received September 9, 1983. Accepted October 27, 1983.

The detailed structure of two ribosomal DNA (rDNA) clones CL-1 and HA-2, from the avian malaria parasite Plasmodium lophurae has been examined using hybridization and electron microscopy. The results demonstrate that the clone CL-1 contains two regions homologous to 25s rRNA of approximately 2200 base pairs (bp) and 450 bp in length, separated by a non homologous region of 240 bp. CL-1 also contains two regions of approximately 1100 bp and 550 bp homologous to 17s rRNA, separated by a non homologous region of 230 bp. The clone HA-2 contains a single region of 670 bp, which 1s homologous to 25s rRNA. This region 1s flanked by non homologous stretches of ONA 940 bp and 110 bp 1n length. As HA-2 is known to be adjacent to CL-1 in the genome (1), these results suggest that the 25s rDNA is interrupted twice, and the 17s rDNA once, by stretches of DNA not found in mature rRNA.


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