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Nucleic Acids Research, 1983, Vol. 11, No. 24 8663-8676
© 1983

MOLECULAR BIOLOGY

Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain

Anton Schamboeck, Alan J. Korman, Alexander Kamb and Jack L. Strominger

Department of Biochemistry and Molecular Biology, Harvard University 7 Divinity Avenue, Cambridge, MA 02138, USA

Received August 10, 1983. Revised November 7, 1983. Accepted November 7, 1983.

A total of 5724 base pairs of a recombinant phage DNA containing a human HLA-DR heavy chain gene including flanking regions has been analyzed. The regions corresponding to all the exons have been identified. The sites of initiation of transcription and polyadenylation have been determined. A large intron of 2399 base pairs separates the first exon containing the 5' untranslated region and the signal peptide from the second exon containing the N-terminal peptide domain.


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