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Nucleic Acids Research, 1983, Vol. 11, No. 24 8809-8816
© 1983

MOLECULAR BIOLOGY

Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene of E. coli

Katherine Koren Richardson, Jennifer Fostel and Thomas R. Skopek

Genetic Toxicology Department, Chemical Industry Institute of Toxicology Research Triangle Park, NC 27709, USA

Received September 16, 1983. Revised November 7, 1983. Accepted November 7, 1983.

The nucleotide sequence of the gpt gene coding for the enzyme xanthine guanine phosphoribosyl transferase has been determined. The gene codes for a protein of molecular weight 16,950. The construction of deletions in the gpt gene which can be used for the genetic analysis of mutations in the gpt gene, is described.


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