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Nucleic Acids Research, 1983, Vol. 11, No. 24 8817-8823
© 1983

MOLECULAR BIOLOGY

Nucleotide sequence of the Esherichia coli xanthine-guanine phosphoribosyl transferase gene

Dickson Pratt and Suresh Subramani

Department of Biology, B-022, Bonner Hall, University of California San Diego, La Jolla, CA 92093, USA

Received October 6, 1983. Revised November 7, 1983. Accepted November 7, 1983.

The Escherichia coli gene conding for the enzyme xanthine-guanine phosphoribosyl transferase (gpt) has been widely used as a dominant selectable marker in a variety of mammalian cells. We have determined the complete nucleotide sequence of the 1057 base pair (bp) segment of DNA containing this gene. The coding sequence for the enzyme is 456 nucleotides long and can code for a 152 amino acid (16.9 Kd) polypeptide. A comparison of the amino acid sequence of the bacterial enzyme with that of the mammalian hypoxanthine-guanine phosphoribosyl transferase (hprt) reveals no significant homology between the two polypeptides.


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