Nucleic Acids Research, 1983, Vol. 11, No. 24 8847-8859
© 1983
MOLECULAR BIOLOGY |
The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end
Department of Microbiology and Immunology, Curriculum in Genetics, and Program in Molecular Biology and Biotechnology, University of North Carolina Chapel Hill, NC 27514, USA
Received September 6, 1983. Revised November 8, 1983. Accepted November 8, 1983.
We have characterized a large repetitive element which has been found at seven different locations within the beta globin locus of the BALB/c mouse. This repeat has an unusual structure in that each of the different members has the same end of the element conserved while the other end terminates at a different point in each repeat member. The sequences within the repeats from the beta globin locus have homology with other repetitive families such as the MIF-1, Bam-5, R, and the BamHl families. These were recently proposed (T. Fanning, (1983) Nucleic Acids Res. 11, 5073–5091) to be part of a structure with the same organization which we found in the globin locus. Probing plaques from a BALB/c genomic library with sequences derived from the repeats in the globin locus shows that virtually all of the repeats from this family are organized in a manner consistent with the proposed structure.
*Present address: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
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