Skip Navigation

This Article
Right arrow Print PDF (2794K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (42)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Emorine, L.
Right arrow Articles by Max, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Emorine, L.
Right arrow Articles by Max, E. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1983, Vol. 11, No. 24 8877-8890
© 1983

MOLECULAR BIOLOGY

Structural analysis of a rabbit immunoglobulin x2 J-C locus reveals multiple deletions

Laurent Emorine* and Edward E. Max+

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20205, USA

+To whom correspondence should be addressed

Received August 29, 1983. Revised November 14, 1983. Accepted November 14, 1983.

We previously reported that domestic rabbits harbor at least two DNA sequences that hybridize strongly to immunoglobulin k C region probes in Southern blots. One of these was cloned from a domestic b4 rabbit and identified as the gene for the nominal b4 allotype k chain which is expressed at high levels. We now have cloned (from a b4 rabbit) the other homologous sequence and find that it encodes a k chain nearly identical to the k2 chain of "bas" rabbits, which is not normally expressed at detectable levels in domestic rabbits. Sequence analysis of this k2 chain reveals a Jk-Ck locus with no obvious coding sequence defects that could explain its low expression. However, several base changes in a putative enhancer region as well as deletions (totalling about 1.5 kb) in the J-C intron might be related to low expression. The comparison between these two k genes raises questions about the selective pressures operating during the evolution of this gene system.

*Current address: Laboratory of Molecular Immunology, Institut J. Monod, University Paris VII, 2 Place Jussieu 75221, Paris Cedex 05, France


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Yi, P. Wu, K. W. Trevorrow, L. Claflin, and W. T. Garrard
Evidence That the Ig{kappa} Gene MAR Regulates the Probability of Premature V-J Joining and Somatic Hypermutation
J. Immunol., May 15, 1999; 162(10): 6029 - 6039.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.