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Nucleic Acids Research, 1983, Vol. 11, No. 24 8915-8929
© 1983

MOLECULAR BIOLOGY

Structural and evolutionary analysis of the two chimpanzee {alpha}-globin mRNAs

Stephen A. Liebhaber1 and Kathi A. Begley2

Howard Hughes Medical Institute Laboratory, and Division of Molecular Hematology, Department of Medicine, University of California San Francisco, CA 94143, USA

Received August 15, 1983. Revised November 8, 1983. Accepted November 8, 1983.

Two distinct {alpha}-globin mRNAs were detected in chimpanzee reticulocyte mRNA using a primer extension assay. DNA copies of these two mRNAs were cloned in the bacterial plasmid pBR322, and their sequence was determined. The two {alpha}-globin mRNAs have obvious structural homology to the two human {alpha}-globin mRNAs, {alpha}1 and {alpha}2. Comparison of the two chimpanzee {alpha}-globin mRNAs to each other and to their corresponding human counterparts revealed evidence of a recent gene conversion in the human {alpha}-globin complex and a marked heterogeneity in the rate of structural divergence within the {alpha}-globin gene.

1Present address: Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

2Present address: Codon Inc., Brisbane, California, USA


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S. Liebhaber, E. Rappaport, F. Cash, S. Ballas, E Schwartz, and S Surrey
Hemoglobin I mutation encoded at both alpha-globin loci on the same chromosome: concerted evolution in the human genome
Science, December 21, 1984; 226(4681): 1449 - 1451.
[Abstract] [PDF]


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