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Nucleic Acids Research, 1983, Vol. 11, No. 4 1133-1142
© 1983

MOLECULAR BIOLOGY

Lambda lg constant region genes are translocated to chromosome 8 in Burkitt's lymphoma with t(8:22

Albert de la Chapelte1,4,*, Gilbert Lenoir2, Joëlle Bouè3, Andre Bouè3, Pia Gallano3, Cècile Huerre4, Marie-France Szajnert4, Marc Jeanpierre4, Jean-Marc LaloueP5 and Jean-Claude Kaplan4

1Department of Medical Genetics, University of Helsinki 00290 Helsinki 29, Finland 2International Agency for Research on Cancer 69372 Lyon 3Groupe de Recherches de Biologic Prènatale INSERM U 73, Château de Longchamp, 75016 Paris, Franc 4Institut de Pathologie Molècuiaire, INSERM U 129, Facultè de Mèdecine Cochin-Port-Royal, 75014 Paris, France. 5Laboratorire de Anthropologie Biologique Paris VII,75006 Paris, France

*To whom correspondence should be sent

Received December 14, 1982. Accepted January 25, 1983.

By in situ hybridization of normal human chromosomes with a cloned genomic probe specific for the constant region of the lambda immunoglobulin genes, band 22q11 was preferentially labelled. In two cell lines with t(8;22) derived from Burkitt's lymphoma a strong signal was noted on the 8q chromosome derivative, indicating that the constant region of the lambda Ig gene cluster was translocated from chromosome 22 to chromosome 8. In addition, the signal observed on the 22q- derivative chromosome was stronger than the background in one of the two cell lines tested, but not in the other. The implications are that the break point in chromosome 22 in some cases lies within the Ig gene itself or between clusters of such genes, and that different cases have different break points.


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