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Nucleic Acids Research, 1983, Vol. 11, No. 4 1151-1166
© 1983

MOLECULAR BIOLOGY

Simultaneous analysis of conformation and transcription of A and B groups of vitellogenin genes in male and female Xenopus daring primary and secondary activation by estrogen

John L. Williams and Jamshed R. Tata

National Institute for Medical Research Mill Hill, London NW7 1AA UK

Received December 1, 1982. Revised January 13, 1983. Accepted January 20, 1983.

In male Xenovus, primary estvadiol administration results in non–coordinate activaivon in the liver of the A and B groups of vitellogenin genes, both as judged by transcription and DNase I sensitivity in isolated nuclei, B group genes being activated preferentially in the first 20 hr. Secondary induction in males or "primary" induction in females results in a coordinate and equal transcription of these two groups of genes. The elevated trans–criptional activity following primary estrogen stimulation returns to low levels rapidly but the high DNaee I sensitivity of these genes persists for 2-3 months. A non–coordinate activation of the A and B groups of vitellogenin genes is however re-established in response to a second administration of eszradiol 8 months after primary stimulation of male Xenopus.


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