Nucleic Acids Research, 1983, Vol. 11, No. 5 1475-1489
© 1983
MOLECULAR BIOLOGY |
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Departments of Biological Chemistry and Genetics, Division of Biology and Biomedical Sciences Washington University School of Medicine, St. Louis, MO 63110, USA
*To whom correspondence should be addressed.
Received November 8, 1982. Revised January 18, 1983. Accepted January 18, 1983.
We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters. Conditions of extraction and assay have been optimized for maximum activity using the major late promoter of adenovirus 2. The extract also directs accurate transcription initiation from other adenovirus promoters and cellular promoters. The extract also directs accurate transcription initiation from class III promoters (tRNA and Ad 2 VA).
+Permanent address: Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
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 J. Borlak and H. S. Jenke Cross-talk between Aryl Hydrocarbon Receptor and Mitogen-Activated Protein Kinase Signaling Pathway in Liver Cancer through c-raf Transcriptional Regulation Mol. Cancer Res., August 1, 2008; 6(8): 1326 - 1336. [Abstract] [Full Text] [PDF]
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 T. Tsutsui, H. Umemura, A. Tanaka, F. Mizuki, Y. Hirose, and Y. Ohkuma Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation Genes Cells, August 1, 2008; 13(8): 817 - 826. [Abstract] [Full Text] [PDF]
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A. Walczak-Drzewiecka, M. Ratajewski, W. Wagner, and J. Dastych HIF-1{alpha} Is Up-Regulated in Activated Mast Cells by a Process That Involves Calcineurin and NFAT J. Immunol., August 1, 2008; 181(3): 1665 - 1672. [Abstract] [Full Text] [PDF]
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P. Cloutier, J. Toutant, L. Shkreta, S. Goekjian, T. Revil, and B. Chabot Antagonistic Effects of the SRp30c Protein and Cryptic 5 ' Splice Sites on the Alternative Splicing of the Apoptotic Regulator Bcl-x J. Biol. Chem., August 1, 2008; 283(31): 21315 - 21324. [Abstract] [Full Text] [PDF]
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 T. K. Hailemariam, C. Huan, J. Liu, Z. Li, C. Roman, M. Kalbfeisch, H. H. Bui, D. A. Peake, M.-S. Kuo, G. Cao, et al. Sphingomyelin Synthase 2 Deficiency Attenuates NF{kappa}B Activation Arterioscler. Thromb. Vasc. Biol., August 1, 2008; 28(8): 1519 - 1526. [Abstract] [Full Text] [PDF]
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 J. M. Izquierdo Fas Splicing Regulation during Early Apoptosis Is Linked to Caspase-mediated Cleavage of U2AF65 Mol. Biol. Cell, August 1, 2008; 19(8): 3299 - 3307. [Abstract] [Full Text] [PDF]
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N. Patel, C. S. Gonsalves, P. Malik, and V. K. Kalra Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1{alpha} Blood, August 1, 2008; 112(3): 856 - 865. [Abstract] [Full Text] [PDF]
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K. Fronz, S. Otto, K. Kolbel, U. Kuhn, H. Friedrich, A. Schierhorn, A. G. Beck-Sickinger, A. Ostareck-Lederer, and E. Wahle Promiscuous Modification of the Nuclear Poly(A)-binding Protein by Multiple Protein-arginine Methyltransferases Does Not Affect the Aggregation Behavior J. Biol. Chem., July 18, 2008; 283(29): 20408 - 20420. [Abstract] [Full Text] [PDF]
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A. Thakur, Y. Sun, A. Bollig, J. Wu, H. Biliran, S. Banerjee, F. H. Sarkar, and D. J. Liao Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells Clin. Cancer Res., July 15, 2008; 14(14): 4427 - 4436. [Abstract] [Full Text] [PDF]
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S. Chen, J. Gluhak-Heinrich, M. Martinez, T. Li, Y. Wu, H.-H. Chuang, L. Chen, J. Dong, I. Gay, and M. MacDougall Bone Morphogenetic Protein 2 Mediates Dentin Sialophosphoprotein Expression and Odontoblast Differentiation via NF-Y Signaling J. Biol. Chem., July 11, 2008; 283(28): 19359 - 19370. [Abstract] [Full Text] [PDF]
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 H.-W. Wang, M. Muguira, W.-D. Liu, T. Zhang, C. Chen, R. Aucoin, M. B Breslin, and M. S Lan Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription J. Endocrinol., July 1, 2008; 198(1): 29 - 39. [Abstract] [Full Text] [PDF]
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P.-Y. Liu, J. Y.-H. Chan, H.-C. Lin, S.-L. Wang, S.-T. Liu, C.-L. Ho, L.-C. Chang, and S.-M. Huang Modulation of the Cyclin-Dependent Kinase Inhibitor p21WAF1/Cip1 Gene by Zac1 through the Antagonistic Regulators p53 and Histone Deacetylase 1 in HeLa Cells Mol. Cancer Res., July 1, 2008; 6(7): 1204 - 1214. [Abstract] [Full Text] [PDF]
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 Y. Ye, J. D. Martinez, R. J. Perez-Polo, Y. Lin, B. F. Uretsky, and Y. Birnbaum The role of eNOS, iNOS, and NF-{kappa}B in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H343 - H351. [Abstract] [Full Text] [PDF]
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H. K. J. Pessa, C. L. Will, X. Meng, C. Schneider, N. J. Watkins, N. Perala, M. Nymark, J. J. Turunen, R. Luhrmann, and M. J. Frilander From the Cover: Minor spliceosome components are predominantly localized in the nucleus PNAS, June 24, 2008; 105(25): 8655 - 8660. [Abstract] [Full Text] [PDF]
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O. Aygun, J. Svejstrup, and Y. Liu A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin PNAS, June 24, 2008; 105(25): 8580 - 8584. [Abstract] [Full Text] [PDF]
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E. D. Rubio, D. J. Reiss, P. L. Welcsh, C. M. Disteche, G. N. Filippova, N. S. Baliga, R. Aebersold, J. A. Ranish, and A. Krumm CTCF physically links cohesin to chromatin PNAS, June 17, 2008; 105(24): 8309 - 8314. [Abstract] [Full Text] [PDF]
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B. A. Thompson, V. Tremblay, G. Lin, and D. A. Bochar CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates {beta}-Catenin Target Genes Mol. Cell. Biol., June 15, 2008; 28(12): 3894 - 3904. [Abstract] [Full Text] [PDF]
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A. Yokoyama, S. Takezawa, R. Schule, H. Kitagawa, and S. Kato Transrepressive Function of TLX Requires the Histone Demethylase LSD1 Mol. Cell. Biol., June 15, 2008; 28(12): 3995 - 4003. [Abstract] [Full Text] [PDF]
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K. Tran and J. D. Gralla Control of the Timing of Promoter Escape and RNA Catalysis by the Transcription Factor IIB Fingertip J. Biol. Chem., June 6, 2008; 283(23): 15665 - 15671. [Abstract] [Full Text] [PDF]
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S. Rudel, A. Flatley, L. Weinmann, E. Kremmer, and G. Meister A multifunctional human Argonaute2-specific monoclonal antibody RNA, June 1, 2008; 14(6): 1244 - 1253. [Abstract] [Full Text] [PDF]
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D. Stanek, J. Pridalova-Hnilicova, I. Novotny, M. Huranova, M. Blazikova, X. Wen, A. K. Sapra, and K. M. Neugebauer Spliceosomal Small Nuclear Ribonucleoprotein Particles Repeatedly Cycle through Cajal Bodies Mol. Biol. Cell, June 1, 2008; 19(6): 2534 - 2543. [Abstract] [Full Text] [PDF]
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