Nucleic Acids Research, 1983, Vol. 11, No. 5 1475-1489
© 1983
MOLECULAR BIOLOGY |
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Departments of Biological Chemistry and Genetics, Division of Biology and Biomedical Sciences Washington University School of Medicine, St. Louis, MO 63110, USA
*To whom correspondence should be addressed.
Received November 8, 1982. Revised January 18, 1983. Accepted January 18, 1983.
We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters. Conditions of extraction and assay have been optimized for maximum activity using the major late promoter of adenovirus 2. The extract also directs accurate transcription initiation from other adenovirus promoters and cellular promoters. The extract also directs accurate transcription initiation from class III promoters (tRNA and Ad 2 VA).
+Permanent address: Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
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P. Cabart, J. Lee, and I. M. Willis Facilitated Recycling Protects Human RNA Polymerase III from Repression by Maf1 in Vitro J. Biol. Chem., December 26, 2008; 283(52): 36108 - 36117. [Abstract] [Full Text] [PDF]
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 C. L. Peterson and J. C. Hansen Chicken Erythrocyte Histone Octamer Preparation CSH Protocols, December 1, 2008; 2008(13): pdb.prot5112 - pdb.prot5112. [Abstract] [Full Text]
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M. Ohtsuji, F. Katsuoka, A. Kobayashi, H. Aburatani, J. D. Hayes, and M. Yamamoto Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes J. Biol. Chem., November 28, 2008; 283(48): 33554 - 33562. [Abstract] [Full Text] [PDF]
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K. O'Brien, A. J. Matlin, A. M. Lowell, and M. J. Moore The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing J. Biol. Chem., November 28, 2008; 283(48): 33147 - 33154. [Abstract] [Full Text] [PDF]
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D. E. Montoya-Durango, C. S. Velu, A. Kazanjian, M. E. B. Rojas, C. M. Jay, G. D. Longmore, and H. L. Grimes Ajuba Functions as a Histone Deacetylase-dependent Co-repressor for Autoregulation of the Growth Factor-independent-1 Transcription Factor J. Biol. Chem., November 14, 2008; 283(46): 32056 - 32065. [Abstract] [Full Text] [PDF]
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J.-S. Kim, C. Bonifant, F. Bunz, W. S. Lane, and T. Waldman Epitope tagging of endogenous genes in diverse human cell lines Nucleic Acids Res., November 1, 2008; 36(19): e127 - e127. [Abstract] [Full Text] [PDF]
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 A. V. Ougolkov, V. N. Bilim, and D. D. Billadeau Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2 Clin. Cancer Res., November 1, 2008; 14(21): 6790 - 6796. [Abstract] [Full Text] [PDF]
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 I. S. Junttila, K. Mizukami, H. Dickensheets, M. Meier-Schellersheim, H. Yamane, R. P. Donnelly, and W. E. Paul Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4R{alpha}, IL-13R{alpha}1, and {gamma}c regulates relative cytokine sensitivity J. Exp. Med., October 27, 2008; 205(11): 2595 - 2608. [Abstract] [Full Text] [PDF]
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C. L. Himeda, J. A. Ranish, and S. D. Hauschka Quantitative Proteomic Identification of MAZ as a Transcriptional Regulator of Muscle-Specific Genes in Skeletal and Cardiac Myocytes Mol. Cell. Biol., October 15, 2008; 28(20): 6521 - 6535. [Abstract] [Full Text] [PDF]
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D. A. Greer Card, P. B. Hebbar, L. Li, K. W. Trotter, Y. Komatsu, Y. Mishina, and T. K. Archer Oct4/Sox2-Regulated miR-302 Targets Cyclin D1 in Human Embryonic Stem Cells Mol. Cell. Biol., October 15, 2008; 28(20): 6426 - 6438. [Abstract] [Full Text] [PDF]
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 M. A. Wassef, D. Chomette, M. Pouilhe, A. Stedman, E. Havis, C. Desmarquet-Trin Dinh, S. Schneider-Maunoury, P. Gilardi-Hebenstreit, P. Charnay, and J. Ghislain Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors Development, October 15, 2008; 135(20): 3369 - 3378. [Abstract] [Full Text] [PDF]
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S.-h. Kim, A. R. Davalos, S.-J. Heo, F. Rodier, Y. Zou, C. Beausejour, P. Kaminker, S. M. Yannone, and J. Campisi Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes J. Cell Biol., October 14, 2008; 181(3): 447 - 460. [Abstract] [Full Text] [PDF]
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K. J. Stanya, Y. Liu, A. R. Means, and H.-Y. Kao Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT J. Cell Biol., October 6, 2008; 183(1): 49 - 61. [Abstract] [Full Text] [PDF]
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A. Zhou, A. C. Ou, A. Cho, E. J. Benz Jr., and S.-C. Huang Novel Splicing Factor RBM25 Modulates Bcl-x Pre-mRNA 5' Splice Site Selection Mol. Cell. Biol., October 1, 2008; 28(19): 5924 - 5936. [Abstract] [Full Text] [PDF]
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D. L. C. van den Berg, W. Zhang, A. Yates, E. Engelen, K. Takacs, K. Bezstarosti, J. Demmers, I. Chambers, and R. A. Poot Estrogen-Related Receptor Beta Interacts with Oct4 To Positively Regulate Nanog Gene Expression Mol. Cell. Biol., October 1, 2008; 28(19): 5986 - 5995. [Abstract] [Full Text] [PDF]
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J. C.Y. Cheung, B. Salerno, and L. A. Hanakahi Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase Nucleic Acids Res., October 1, 2008; 36(17): 5713 - 5726. [Abstract] [Full Text] [PDF]
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H. Wang, S. T. R. Walsh, and M. R. Parthun Expanded binding specificity of the human histone chaperone NASP Nucleic Acids Res., October 1, 2008; 36(18): 5763 - 5772. [Abstract] [Full Text] [PDF]
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S. Priego, F. Feddi, P. Ferrer, S. Mena, M. Benlloch, A. Ortega, J. Carretero, E. Obrador, M. Asensi, and J. M. Estrela Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism Mol. Cancer Ther., October 1, 2008; 7(10): 3330 - 3342. [Abstract] [Full Text] [PDF]
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C. Mertens and R. G. Roeder Different Functional Modes of p300 in Activation of RNA Polymerase III Transcription from Chromatin Templates Mol. Cell. Biol., September 15, 2008; 28(18): 5764 - 5776. [Abstract] [Full Text] [PDF]
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Y. Hao and I. G. Macara Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1 J. Cell Biol., September 8, 2008; 182(5): 827 - 836. [Abstract] [Full Text] [PDF]
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 C. Thangavel and B. H. Shapiro Inherent Sexually Dimorphic Expression of Hepatic CYP2C12 Correlated with Repressed Activation of Growth Hormone-Regulated Signal Transduction in Male Rats Drug Metab. Dispos., September 1, 2008; 36(9): 1884 - 1895. [Abstract] [Full Text] [PDF]
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D. M. Mauger, C. Lin, and M. A. Garcia-Blanco hnRNP H and hnRNP F Complex with Fox2 To Silence Fibroblast Growth Factor Receptor 2 Exon IIIc Mol. Cell. Biol., September 1, 2008; 28(17): 5403 - 5419. [Abstract] [Full Text] [PDF]
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