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Nucleic Acids Research, 1983, Vol. 11, No. 5 1475-1489
© 1983


MOLECULAR BIOLOGY

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

John David Dignani*, Russell M. Lebovitz and Robert G. Roeder+

Departments of Biological Chemistry and Genetics, Division of Biology and Biomedical Sciences Washington University School of Medicine, St. Louis, MO 63110, USA

*To whom correspondence should be addressed.

Received November 8, 1982. Revised January 18, 1983. Accepted January 18, 1983.

We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters. Conditions of extraction and assay have been optimized for maximum activity using the major late promoter of adenovirus 2. The extract also directs accurate transcription initiation from other adenovirus promoters and cellular promoters. The extract also directs accurate transcription initiation from class III promoters (tRNA and Ad 2 VA).


+Permanent address: Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA


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Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes
Mol. Cell. Biol., January 1, 2009; 29(1): 281 - 301.
[Abstract] [Full Text] [PDF]


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RNAHome page
A. N. Kuhn, M. A. van Santen, A. Schwienhorst, H. Urlaub, and R. Luhrmann
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation
RNA, January 1, 2009; 15(1): 153 - 175.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
O. Dakhova, D. O'Day, N. Kinet, N. Yucer, M. Wiese, G. Shetty, and P. Ducy
Dickkopf-Like1 Regulates Postpubertal Spermatocyte Apoptosis and Testosterone Production
Endocrinology, January 1, 2009; 150(1): 404 - 412.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
A. Choudhury, H. Zhao, F. Jalali, S. AL Rashid, J. Ran, S. Supiot, A. E. Kiltie, and R. G. Bristow
Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
Mol. Cancer Ther., January 1, 2009; 8(1): 203 - 213.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
L. Shi, S. Ko, S. Kim, I. Echchgadda, T.-S. Oh, C. S. Song, and B. Chatterjee
Loss of Androgen Receptor in Aging and Oxidative Stress through Myb Protooncoprotein-regulated Reciprocal Chromatin Dynamics of p53 and Poly(ADP-ribose) Polymerase PARP-1
J. Biol. Chem., December 26, 2008; 283(52): 36474 - 36485.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
P. Cabart, J. Lee, and I. M. Willis
Facilitated Recycling Protects Human RNA Polymerase III from Repression by Maf1 in Vitro
J. Biol. Chem., December 26, 2008; 283(52): 36108 - 36117.
[Abstract] [Full Text] [PDF]


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CSH ProtocolsHome page
C. L. Peterson and J. C. Hansen
Chicken Erythrocyte Histone Octamer Preparation
CSH Protocols, December 1, 2008; 2008(13): pdb.prot5112 - pdb.prot5112.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
M. Ohtsuji, F. Katsuoka, A. Kobayashi, H. Aburatani, J. D. Hayes, and M. Yamamoto
Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes
J. Biol. Chem., November 28, 2008; 283(48): 33554 - 33562.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. O'Brien, A. J. Matlin, A. M. Lowell, and M. J. Moore
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing
J. Biol. Chem., November 28, 2008; 283(48): 33147 - 33154.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
D. E. Montoya-Durango, C. S. Velu, A. Kazanjian, M. E. B. Rojas, C. M. Jay, G. D. Longmore, and H. L. Grimes
Ajuba Functions as a Histone Deacetylase-dependent Co-repressor for Autoregulation of the Growth Factor-independent-1 Transcription Factor
J. Biol. Chem., November 14, 2008; 283(46): 32056 - 32065.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
J.-S. Kim, C. Bonifant, F. Bunz, W. S. Lane, and T. Waldman
Epitope tagging of endogenous genes in diverse human cell lines
Nucleic Acids Res., November 1, 2008; 36(19): e127 - e127.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
A. V. Ougolkov, V. N. Bilim, and D. D. Billadeau
Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2
Clin. Cancer Res., November 1, 2008; 14(21): 6790 - 6796.
[Abstract] [Full Text] [PDF]


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JEMHome page
I. S. Junttila, K. Mizukami, H. Dickensheets, M. Meier-Schellersheim, H. Yamane, R. P. Donnelly, and W. E. Paul
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4R{alpha}, IL-13R{alpha}1, and {gamma}c regulates relative cytokine sensitivity
J. Exp. Med., October 27, 2008; 205(11): 2595 - 2608.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
C. L. Himeda, J. A. Ranish, and S. D. Hauschka
Quantitative Proteomic Identification of MAZ as a Transcriptional Regulator of Muscle-Specific Genes in Skeletal and Cardiac Myocytes
Mol. Cell. Biol., October 15, 2008; 28(20): 6521 - 6535.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
D. A. Greer Card, P. B. Hebbar, L. Li, K. W. Trotter, Y. Komatsu, Y. Mishina, and T. K. Archer
Oct4/Sox2-Regulated miR-302 Targets Cyclin D1 in Human Embryonic Stem Cells
Mol. Cell. Biol., October 15, 2008; 28(20): 6426 - 6438.
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DevelopmentHome page
M. A. Wassef, D. Chomette, M. Pouilhe, A. Stedman, E. Havis, C. Desmarquet-Trin Dinh, S. Schneider-Maunoury, P. Gilardi-Hebenstreit, P. Charnay, and J. Ghislain
Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors
Development, October 15, 2008; 135(20): 3369 - 3378.
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JCBHome page
S.-h. Kim, A. R. Davalos, S.-J. Heo, F. Rodier, Y. Zou, C. Beausejour, P. Kaminker, S. M. Yannone, and J. Campisi
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes
J. Cell Biol., October 14, 2008; 181(3): 447 - 460.
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JCBHome page
K. J. Stanya, Y. Liu, A. R. Means, and H.-Y. Kao
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
J. Cell Biol., October 6, 2008; 183(1): 49 - 61.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
A. Zhou, A. C. Ou, A. Cho, E. J. Benz Jr., and S.-C. Huang
Novel Splicing Factor RBM25 Modulates Bcl-x Pre-mRNA 5' Splice Site Selection
Mol. Cell. Biol., October 1, 2008; 28(19): 5924 - 5936.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
D. L. C. van den Berg, W. Zhang, A. Yates, E. Engelen, K. Takacs, K. Bezstarosti, J. Demmers, I. Chambers, and R. A. Poot
Estrogen-Related Receptor Beta Interacts with Oct4 To Positively Regulate Nanog Gene Expression
Mol. Cell. Biol., October 1, 2008; 28(19): 5986 - 5995.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
J. C.Y. Cheung, B. Salerno, and L. A. Hanakahi
Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase
Nucleic Acids Res., October 1, 2008; 36(17): 5713 - 5726.
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Nucleic Acids ResHome page
H. Wang, S. T. R. Walsh, and M. R. Parthun
Expanded binding specificity of the human histone chaperone NASP
Nucleic Acids Res., October 1, 2008; 36(18): 5763 - 5772.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
S. Priego, F. Feddi, P. Ferrer, S. Mena, M. Benlloch, A. Ortega, J. Carretero, E. Obrador, M. Asensi, and J. M. Estrela
Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism
Mol. Cancer Ther., October 1, 2008; 7(10): 3330 - 3342.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
C. Mertens and R. G. Roeder
Different Functional Modes of p300 in Activation of RNA Polymerase III Transcription from Chromatin Templates
Mol. Cell. Biol., September 15, 2008; 28(18): 5764 - 5776.
[Abstract] [Full Text] [PDF]


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JCBHome page
Y. Hao and I. G. Macara
Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1
J. Cell Biol., September 8, 2008; 182(5): 827 - 836.
[Abstract] [Full Text] [PDF]


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Drug Metab. Dispos.Home page
C. Thangavel and B. H. Shapiro
Inherent Sexually Dimorphic Expression of Hepatic CYP2C12 Correlated with Repressed Activation of Growth Hormone-Regulated Signal Transduction in Male Rats
Drug Metab. Dispos., September 1, 2008; 36(9): 1884 - 1895.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
D. M. Mauger, C. Lin, and M. A. Garcia-Blanco
hnRNP H and hnRNP F Complex with Fox2 To Silence Fibroblast Growth Factor Receptor 2 Exon IIIc
Mol. Cell. Biol., September 1, 2008; 28(17): 5403 - 5419.
[Abstract] [Full Text] [PDF]



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