Skip Navigation

This Article
Right arrow Print PDF (3852K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Furdon, P. J.
Right arrow Articles by Altman, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Furdon, P. J.
Right arrow Articles by Altman, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1983, Vol. 11, No. 5 1491-1505
© 1983

MOLECULAR BIOLOGY

A G43 to U43 mutation in E. coli tRNATyrsu3+ which affects processing by RNase P

Paul J. Furdon, Cecilia Guerrier-Takada and Sidney Altman

Department of Biology, Yale University New Haven, CT 06520, USA

Received October 25, 1982. Revised February 3, 1983. Accepted February 3, 1983.

A novel mutation in the anticodon stem of E. coli tRNA1Tyrsu3+ (G43 to U43) has been characterized. The gene c{oplus}ding for the mutant tRNA, carried by phage Ø80DHA61.3 a derivative of Ø80psu3+su0 , produces only 20% of mature suppressor tRNA as compared with Ø80psu3. Both the mutant tRNA precursor and mature tRNA have an altered conformation. The precursor tRFormulaA coded for by Ø80DHA61.3 is processed by RNase P more slowly than the suØ3. prFormulacursor and does not form as stable an enzyme-substrate complex as does su3, precursor. Ø80DHA61.3 also +contains a large Formulaeletion which begins in the spFormulacer region between the su, gene and the su3+. gene, extends through the su0. gene and includes most of the repeated region following the tRNA genes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.