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Nucleic Acids Research, 1983, Vol. 11, No. 6 1803-1817
© 1983

MOLECULAR BIOLOGY

Association of two different repetitive DNA dements near immunoglobulin light chain genes

Ronald Wilson

Department of Microbiology and Immunology, University of Washington, Seattle, WA 98195, USA.

Received December 17, 1982. Accepted February 14, 1983.

Sequence studies of repetitive DNA elements approximately 6 kb 3’ of the mouse Immunoglobulin CK region gene show that the R element located there (Gebhard et al. (1982) J. Mol. B1ol. 157., 453-471) is adjacent to a 500 base pair long element which shows 80% homology to the BAM5 element sequenced by Fanning (Nuc. Acids Res. (1982), l0, 5003-5013). Neither the BAM5 element nor the R element itself is surrounded by a direct repeat, but the composite element (BAMS + R) 1s surrounded by a 15 base pair direct repeat (with one mismatch). Direct repeats, consisting of target site sequences that surround a repetitive DNA element, are thought to arise during the insertion of the element at that site. It therefore appears that the BAM5 and R elements Interacted and Inserted as a linked entity. The existence of other BAM5/R composites throughout the mouse {gamma} chain locus Indicates that BAM5–R cooperation 1s not a rare event.


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