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Nucleic Acids Research, 1983, Vol. 11, No. 7 2155-2164
© 1983

MOLECULAR BIOLOGY

Nuclear matrix–DNA complex resulting from EcoR1 digestion of HeLa nucleoids is enriched for DNA replicating forks

Manuel S. Valenzuela*, Gerald C. Muelier+ and Santanu Dasgupta+

*Biophysics Laboratory +McArdle Laboratory for cancer Research, University of Eisconsin–Madison Madison, WI 53706, USA

Received October 5, 1982. Accepted March 9, 1983.

Upon treatment of HeLa nucleoids with EcoR1 restriction enzyme, a minute fraction of the DNA remains attached to the nuclear matrix. This matrix–DNA complex appears to be composed of a unique set of proteins. Electron microscopic analysis of the DNA fragments present shows an enrichment for HeLa DNA replicating forks.


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