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Nucleic Acids Research, 1983, Vol. 11, No. 9 2541-2550
© 1983

MOLECULAR BIOLOGY

A frameshift addition causes silencing of the {delta}-gtobin gene in an old world monkey, an anubis(Papio doguera)

Akinon Kimura and Yasuyuki Takagi

Department of Biochemistry, Kyushu University 60 School of Medicine Fukuoka 812, Japan

Received March 7, 1983. Revised April 11, 1983. Accepted April 11, 1983.

A{delta}-globin gene of an anubis, Papio doauera. was cloned, and the nucleotide sequence of a region of about 2,000 bp Including the gene was determined. In comparison with that of pSP3, a {delta}-globin clone from the gene library of a normal Japanese, the anubis {delta}-globin gene showed one base addition 1n the second exon at the codon for amino acid 55, generating a termination codon at the new 59th codon. The other differences found 1n the region analyzed were not considered to affect expression of the {delta}-globin gene. Therefore, 1t was concluded that this frameshift addition was at least one of the causes of silencing of the {delta}-globin gene 1n the anubis. In addition, from the sequence divergence 1n the {delta}-globin gene, the period of this silencing was estimated to be at most 4 million years, and the di-vergece of anubis occurred at most 30 million years ago.


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