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Nucleic Acids Research, 1983, Vol. 11, No. 9 2575-2584
© 1983

CHEMISTRY

Improvements in the phosphoramidite procedure for the synthesis of oligodeoxyribonucleotides

Thomas Dörper and Emst-L Winnacker

Department of Biochemistry, University of Munich Karlstrasse 23, D-8000 MUnchen 2, FRG

Received February 28, 1983. Accepted April 7, 1983.

The paper describes an improved method for the synthesis of oligodeoxyribo-nucleotides using phosphoramidite chemistry. Our procedure relies on novel phosphoramidite intermediates, the deoxyribonucleoside-3'-morpholino-meth-oxyphosphins. These compounds are extremely stable and can be purified readily. Condensation reactions during solid-phase synthesis can thus be performed with high efficiency and result in a high yield synthesis of long chain oligodeoxyribonucleotides.


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