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Nucleic Acids Research, 1983, Vol. 11, No. 9 2893-2905
© 1983

CHEMISTRY

A double helix B-type geometry based on high-resohition proton NMR of single-helical DNA fragments: d(TA)5d(TA)5

J.-R. Mellema, P.N.van Kampen, C.N. Carlson*, H.E. Bosshard* and C. Alton

Gorlacus Laboratories, State University of Leiden P.O. Box 9502, 2300 RA Leiden, The Netherlands *European Molecular Biology Laboratory Meyerhofstrasse 1, Postfach 10.2209, 6900 Hadelbere. FRG

Received February 9, 1983. Accepted April 12, 1983.

A single-helical B-type geometry is presented based on 1H NMR observations on d(TATA) and several other small single-helical DNA fragments. The structure is extended to one complete turn of double-helical DNA and its characteristics are compared with other known B-type structures.


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