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Nucleic Acids Research, 1984, Vol. 12, No. 10 4051-4061
© 1984

CHEMISTRY

In situ activation of bis-dialkylaminophosphines—a new method for synthesizing deoxyoligonucleotides on polymer supports

A.D. Barone, J.-Y. Tang and M.H. Caruthers*

Department of Chemistry, University of Colorado Boulder, CO 80309, USA

*To whom correspondence should be addressed

Received April 17, 1984. Accepted May 3, 1984.

Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis-dialkylaminophosphines, and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.


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