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Nucleic Acids Research, 1984, Vol. 12, No. 11 4531-4538
© 1984

MOLECULAR BIOLOGY

Evolution of haptoglobin: comparison of complementary DNA encoding Hp{alpha}1S and Hp{alpha}2FS

Jill L. Brune, Funmei Yang, Don R. Barnett and Barbara H. Bowman

Department of Cellular and Structural Biology, University of Texas Health Science Center 7703 Floyd Curl Drive, San Antonio, TX 78284, USA

Received February 16, 1984. Revised May 1, 1984. Accepted May 1, 1984.

Haptoglobin is a transport glycoprotein which removes free hemoglobin from the circulation of vertebrates. In human populations haptoglobin is polymorphic due to three alleles, Hp{alpha}1F, Hp{alpha}1S and Hp{alpha}2. The Hp{alpha}2 allele is roughly twice the length of the Hp{alpha}1 alleles and is the product of a partial gene duplication possibly resulting from an unequal crossover event in a heterozygous genotype Hp{alpha}1F/Hp{alpha}1S. In the study described here we compare the cDNA encoding Hp{alpha}1S to that encoding Hp{alpha}2FS. Both have a leader sequence followed by the genotypic {alpha} chain sequence, a ß sequence and an untranslated sequence in the 3' end. The cDNA encoding Hp{alpha}2FS is composed of {alpha}1F and {alpha}1S domains differing by four nucleotide replacements. Hp{alpha}1S cDNA contains the same replacement site mutations found in the {alpha}1S domain of Hp{alpha}2FS, indicating that this coding region has sustained few, if any, mutations since its incorporation into the Hp{alpha}2FS gene.


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