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Nucleic Acids Research, 1984, Vol. 12, No. 12 5087-5099
© 1984

MOLECULAR BIOLOGY

Homology between two EBV early genes and HSV ribonudeotide reductase and 38K genes

Toby Gibson, Peter Stockwell1,2, Michelle Ginsburg1 and Bart Barrell

1Imperial Cancer Research Fund, Lincoln's Inn Fidds London WC2A 3PX, UK MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH

Received April 11, 1984. Revised May 24, 1984. Accepted May 24, 1984.

Computer-matching of amino acid sequences predicted from the complete EBV DNA sequence against the known HSV gene sequences has revealed significant homology between two EBV reading frames and the HSV1 and ESV2 140K and 38K proteins which are associated with ribonudeotide reductase activity. The two genes are arranged tandemly as in HSV though it appears that, unlike HSV, the two mRNAs are not 3' co-terminal. We have mapped two promoters predicted from the DNA sequence for these genes and shown them to be transcribed at a similar stage in the virus life cycle to that of the HSV genes.

2Permanent address: Depatment of biochemistry, University of Otago, Box 56, Dunedin, New Zealand


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