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Nucleic Acids Research, 1984, Vol. 12, No. 13 5249-5263
© 1984

MOLECULAR BIOLOGY

Composite human VKgenes and a model of their evolution

Hans-Rainer Jeenichen, 1, Michael Pech, Werner Lindenmaier*, Nobert Wildgruber and Hans G. Zachau

Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München *Gesellschaft für Biotechnologische Forschung mbH Braunschweig-Stöckheim, FRG

Received May 2, 1984. Accepted June 1, 1984.

A phage library and two cosmid libraries were screened for human VK genes. Two recombinant phage and four cosmid clones were analysed in detail by restriction mapping and sequencing. Each one contained a single VKI sequence. Two of these six sequences are potentially functional VK genes and four are pseudogenes. Two pseudogenes derived from different genomic DNAs are highly homologous and are therefore either allelic variants or the products of a recent duplication event. Comparisons of our sequences with all fully determined human VKI amino acid and DNA sequences reveal identical segments which at first sight appear like minigenes. But these segments do not coincide with the subregions and some of the segments include both, framework and complementarity determining regions (FR, CDR, ref. 2). The findings may be explained by an evolutionary model generating composite genes by genes conversion and selection.


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