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Nucleic Acids Research, 1984, Vol. 12, No. 13 5277-5285
© 1984

MOLECULAR BIOLOGY

A cytological map of the human X chromosome - evidence for non-random recombination

David A. Hartley1, Kay E. Davies2, Dennis Drayna3, Ray L. White3 and Roberts Williamson

Department of Biochemistry, St. Mary's Hospital Medical School London W2 1PG, UK 3Howard Hughes Medical Institute, University of Utah Medical School Salt Lake City, UT 84732, USA

Received April 26, 1984. Accepted June 12, 1984.

The cytological location of six cloned DNA sequences on the human X chromosome has been determined to a high resolution by direct hybridisa tion ‘in situ’ to metaphase chromosomes. Each locus has been identified using clones which also detect restriction fragment length polymorphisms by Southern hybridisation. The six loci identified are spaced along the chromosome from Xp22 to Xq28. By combining data obtained using this powerful sequence localisation technique with that from hybrid cell panels and from family studies, it is possible to compare physical and genetic distances, and to demonstrate that the frequency of reciprocal genetic exchange is not uniform along the chromosome length.

1 Present address: Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, London NW7, UK

2 Present address: Molecular Genetics Group, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK


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D Drayna and R White
The genetic linkage map of the human X chromosome
Science, November 15, 1985; 230(4727): 753 - 758.
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