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Nucleic Acids Research, 1984, Vol. 12, No. 13 5475-5493
© 1984

CHEMISTRY

Structure of a pleiomeric form of poly d(AT):poly d(AT)

R.P. Millane, J.K. Walker, Struther Arnott, R. Chandrasekaran, D.L. Birdsall and R.L. Ratliff

Department of Biological Sciences, Purdue University West Lafayette, IN 47907 Los Alainos Scientific Laboratory, University of California Los Alamos, NM 87544, USA

Received March 22, 1984. Accepted June 13, 1984.

A chemically simple polynucleotide duplex, poly d(AT):poly d(AT), has been trapped in a fibrous form with a complex helical secondary structure with a large (7.4 nm) axial repeat 24 nucleotides long. The motif which is repeated by the syn elements is a hexanucleotide in which two residues (both TpA) have the less comon gauchs minus conformation at C3-03' and consequently distinctive phosphate orientations. This reinforces earlier conclusions that PypPu nucleotides tend to have different shapes from PupPy nucleotides and that DNA surfaces may signal what base sequences lie beneath them. The morphological differences between this pleiomeric DNA polymer and closely-related, but more symmetrical allomorphs are just as great as those observed in short DNA fragments in crystals.


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