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Nucleic Acids Research, 1984, Vol. 12, No. 14 5583-5588
© 1984

Articles

An altered DNA sequence encompassing the ras gene of Harvey marine sarcoma virus

Shuhei Yasuda*, Masato Furuichi and Eüchi Soeda+

National Institute of Genetics Mishima 411 *Technical Department, Fujiya Confectionery Co., Hatano 257, Japan

+To whom correspondence should be addressed

Received June 5, 1984. Accepted July 3, 1984.

The DNA fragment encompassing the ras gene of Harvey murine sarcoma virus was sequenced and assigned the coding region of a transforming protein, p21, to the sequence. Examination of nucleotide sequence, taken together with the result of analysis of the ras mRNAs (1), has revealed that p21 is encoded from a continuous coding region starting with the 5' proximal initiation codon but not a processed protein. However, there were found several differences between the sequence published by Dhar et. al. (2) and ours, including 9 deletions, 7 substitutions and 2 insertions of nucleotides in the published sequence of 997 nucleotides in length. Among these, one of the substitutions occurring in the coding region resulted in amino acid replacement of glycine by alanine at position 122 of p21 The evidences are presented with some of actual gel autoradiographs.


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