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Nucleic Acids Research, 1984, Vol. 12, No. 14 5779-5787
© 1984

Articles

Human purine nucleoside phosphorylase cDNA sequence and genomic clone characterization

Steven R. Williams*, Judy M. Goddard** and David W. Martin, Jr.*

Howard Hughes Medical Institute, Department of Medicine and Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, and Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, CA 94080, USA

Received May 29, 1984. Accepted June 17, 1984.

The isolation of a cDNA clone containing the complete coding region for human purine nucleoside phosphorylase (PNP) has been described previously. In this report we present the nucleotide sequence of this cDNA clone and compare the derived amino acid sequence, encoding a protein of 32 kilodaltons, with the published amino acid composition.

Using a fragment of the cDNA clone as a probe, human PNP genomic clones from a bacteriophage lambda library have been isolated and the structural organization of the wild type PNP gene determined.

* Current address: Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080.

** Current address: Department of Biology, University of Utah, Salt Lake City, Utah 84112.


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