Skip Navigation

This Article
Right arrow Print PDF (305K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Adams, R.L.P.
Right arrow Articles by Eason, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adams, R.L.P.
Right arrow Articles by Eason, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1984, Vol. 12, No. 14 5869-5877
© 1984

Articles

Increased G+C content of DNA stabilises methyl CpG dinucieotides

R.L.P. Adams and R. Eason

Department of Biochemistiy, University of Glasgow Glasgow G12 8QQ, UK

Received April 26, 1984. Revised June 13, 1984. Accepted June 26, 1984.

The vertebrate genome is a mosaic of regions differing dramatically in their G+C content. Those regions with a high G+C Content contain the expected number of CpG dinucleotides and we propose that following rnethylation these have been protected from deamination by the increased stability of the surrounding DNA duplex. This argument applies both to the microenvironment of the CpG dinucleotide and to whole gene regions.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
K. J. Fryxell and W.-J. Moon
CpG Mutation Rates in the Human Genome Are Highly Dependent on Local GC Content
Mol. Biol. Evol., March 1, 2005; 22(3): 650 - 658.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.