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Nucleic Acids Research, 1984, Vol. 12, No. 15 5969-5978
© 1984

MOLECULAR BIOLOGY

Trans activation of plasmid-borne promoters by adenovirus and several herpes group viruses

R.D. Everett and M. Dunlop

Medical Research Council Virology Unit, Institute of Virology Church Street, Glasgow G11 5JR, UK

Received June 18, 1984. Accepted July 18, 1984.

This paper describes experiments to test the ability of a number of viruses of the Herpes group, and also Adenovirus-2 and SV40, to activate transcription from the Herpes simplex virus-1 glycoprotein D and the rabbit ß-globin promoters. Plasmids containing these genes were transfected into HeLa cells which were then infected with various viruses. Transcriptional activation in trans of the plasmid-borne promoters was monitored by quantitative S1 nuclease analysis of total cytoplasmic RNA isolated after infection. The results showed that Herpes simplex viruses 1 and 2, Pseudorabies virus, Variella Zoster virus, Human Cytomegalovirus, Equine herpes virus-1 and Adenovirus-2 activate transcription from both promoters tested. In contrast, SV40 did not activate transcription in trans in this assay. The possible mechanisms of this activation are discussed.


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