Skip Navigation

This Article
Right arrow Print PDF (2822K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (58)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Kuhn, N. J.
Right arrow Articles by Held, W. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuhn, N. J.
Right arrow Articles by Held, W. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1984, Vol. 12, No. 15 6073-6090
© 1984

MOLECULAR BIOLOGY

Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation in the liver

Nancy J. Kuhn, Mary Woodworth-Gutai, Kenneth W. Gross* and William A. Held

Department of Cell and Tumor Biology, Roswell Park Memorial Institute 666 Elm Street, Buffalo, NY 14263, USA *Department of Molecular Biology, Roswell Park Memorial Institute 666 Elm Street, Buffalo, NY 14263, USA

Received May 15, 1984. Revised July 12, 1984. Accepted July 12, 1984.

The mouse major urinary proteins (MUPs) are the products of a multi-gene family of 30–35 genes whose members exhibit diverse tissue specific, developmental, and hormonal controls. Three cDNA clones corresponding to liver MUP mRNAs have been sequenced. Two of the clones (p499, C57BL/6 and p1057, BALB/c) share strong homology whereas a third clone (p199, C578L/6) has diverged considerably from the others at the nucleic acid (85% homology) and protein (68% homology) levels. The 5' regions of p499 and p199 which show the most sequence divergence were subcloned and shown to hybridize to different liver MUP mRNAs. The p499–5' sequence was expressed in all MUP expressing tissues (liver, lachrymal, submaxillary and mammary) whereas the p199–5' sequence was expressed primarily in the liver and lachrymal. Analysis of liver RNA from mice in different endocrine states indicates that the p499–5' sequence is strongly regulated by thyroxine administration whereas the p199–5' sequence is not. Both sequences appear to be regulated by growth hormone and testosterone. Southern blot analysis of mouse genomic DNA indicates that there are multiple genes homologous to each sequence.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. L. Uprichard, S. F. Wieland, A. Althage, and F. V. Chisari
Transcriptional and posttranscriptional control of hepatitis B virus gene expression
PNAS, February 4, 2003; 100(3): 1310 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
Y. Mechref, L. Zidek, W. Ma, and M. V. Novotny
Glycosylated major urinary protein of the house mouse: characterization of its N-linked oligosaccharides
Glycobiology, March 1, 2000; 10(3): 231 - 235.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Reik, I. Romer, S. C. Barton, M. A. Surani, S. K. Howlett, and J. Klose
Adult phenotype in the mouse can be affected by epigenetic events in the early embryo
Development, November 1, 1993; 119(3): 933 - 942.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
J P Sanford, H J Clark, V M Chapman, and J Rossant
Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse.
Genes & Dev., December 1, 1987; 1(10): 1039 - 1046.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Takahashi, D. R. Chernavvsky, R. A. Gomez, P. Igarashi, H. J. Gitelman, and O. Smithies
Uncompensated polyuria in a mouse model of Bartter's syndrome
PNAS, May 9, 2000; 97(10): 5434 - 5439.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.