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Nucleic Acids Research, 1984, Vol. 12, No. 16 6575-6586
© 1984

MOLECULAR BIOLOGY

Localization of the L1Md family of repeated sequences in the mouse albumin-{alpha}-fetoprotein gene complex

Robin Cooper, Cynthia E. Herzog, Ming-Liang Li, William F. Zapisek1, Peter R. Hoyt, Harry Ratrie, III and John Papaconstantinou*

Department of Human Biological Chemistry and Genetics, Division of Cell Biology/F43, University of Texas Medical Branch Galveston, TX 77550 1Biochemistry Curriculum, Canisius College Buffalo, NY 14208, USA

*To whom reprint requests may be sent

Received May 22, 1984. Accepted July 17, 1984.

Studies on the ß-globin gene complex in the mouse have demonstrated the existence of repeated DNA sequences interspersed throughout the intergenic regions (1,2). These sequences are members of families of middle repetitive sequences and have been mapped to specific intergenic sites in the 60 kbp ß-globin complex. In this study we present evidence that members of this middle repetitive family of DNA sequences, the L1Md family, are interspersed throughout the mouse albumin and {alpha}-fetoprotein gene complex. Unlike those of the ß-globin complex, all of which are found in the intergenic regions, these sequences are localized within intron 12 of the albumin gene and intron 3 of the AFP gene as well as twice in the 13.5 kbp intergenic region that links the albumin gene to the AFP gene.


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