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Nucleic Acids Research, 1984, Vol. 12, No. 17 6663-6671
© 1984

MOLECULAR BIOLOGY

Codon usage can affect efficiency of translation of genes in Escherichia coli

M. Robinson, R. Lilley, S. Little, J.S. Emtage, G. Yarranton, P. Stephens, A. Millican, M. Eaton and G. Humphreys

Division of Molecular Biology, Celltech Limited 250 Bath Road, Slough SL1 4DY, Uk

Received July 19, 1984. Accepted August 14, 1984.

By inserting synthetic oligonucleotides into a highly expressed gene in E.coli it has been shown that unfavourable codon usage can reduce the maximum translation rate of a protein. However, in the case of the codon used (AGC) a significant effect on translation was only seen at very high transcription rates from a gene containing multiple copies of the unfavourable codon.


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