Nucleic Acids Research, 1984, Vol. 12, No. 18 7251-7267
© 1984
MOLECULAR BIOLOGY |
Similarity in gene organization and homology between proteins of animal picomaviruses and a plant comovirus suggest common ancestry of these virus families
+Purdue University, Department of Biological Sciences West Lafayette, IN 47907, USA
State University of New York at Stony Brook, Department of Microbiology, School of Medicine Stony Brook, NY 11794, USA
*To whom reprint requests should be sent
Received May 4, 1984. Revised September 4, 1984. Accepted September 4, 1984.
The amino acid sequences deduced from the nucleic acid sequences of several animal picornaviruses and cowpea mosaic virus (CPMV), a plant virus, were compared. Good homology was found between CPMV and the picornaviruses in the region of the picornavirus 2C (P2-X protein), VPg, 3C pro (proteinase) and 3D pol (RNA polymerase) regions. The CPMV B genome was found to have a similar gene organization to the picornaviruses. A comparison of the 3C pro (proteinase) regions of all of the available picornavirus sequences and CPMV allowed us to identify residues that are completely conserved; of these only two residues, Cys-147 and His-161 (poliovirus proteinase) could be the reactive residues of the active site of a proteinase with analogous mechanism to a known proteinase. We conclude that the proteinases encoded by these viruses are probably cysteine proteinases, mechanistically related, but not homologous to papain.
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