Nucleic Acids Research, 1984, Vol. 12, No. 18 7269-7282
© 1984
MOLECULAR BIOLOGY |
Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses
Purdue University, Department of Biological Sciences West Lafayette, IN 47907, USA
*To whom reprint requests should be sent
Received May 14, 1984. Revised September 4, 1984. Accepted September 4, 1984.
Possible alignments for portions of the genomic codons in eight different plant and animal viruses are presented: tobacco mosaic, brome mosaic, alfalfa mosaic, sindbis, foot-and-mouth disease, polio, encephalomyocarditis, and cowpea mosaic viruses. Since in one of the viruses (polio) the aligned sequence has been identified as an RNA-dependent polymerase, this would imply the identification of the polymerases in the other viruses. A conserved fourteen-residue segment consisting of an Asp-Asp sequence flanked by hydro-phobic residues has also been found in retroviral reverse transcriptases, a bacteriophage, influenza virus, cauliflower mosaic virus and hepatitis B virus, suggesting this span as a possible active site or nucleic add recognition region for the polymerases. Evolutionary implications are discussed.
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