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Nucleic Acids Research, 1984, Vol. 12, No. 19 7435-7453
© 1984

CHEMISTRY

Synthesis and biophysical studies of short oligodeoxynudeotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynudeotide synthesis

T.A. Millican1, G.A. Mock1, M.A. Chauncey1, T.P. Patel1, M.A.W. Eaton1, J. Gunning2, S.D. Cutbush2, S. Neidle2 and J. Mann3

1Dept. Chemistry, Celltech Ltd. 250 Bath Road, Slough SL1 4DY 2Cancer Research Campaign Biomolecular Structure Research Group, Dept. Biophysics, King's College London WC2B 5RL 3Dept. Chemistry, Reading University Whiteknights, Reading RG6 2AP, UK

Received August 17, 1984. Accepted September 14, 1984.

The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-l-phenyl-ß-D-rlbofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing A.C and G.T mismatches.


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