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Nucleic Acids Research, 1984, Vol. 12, No. 1Part1 53-66
© 1984


MAIN-FRAME COMPUTERS

An accelerated algorithm for calculating the secondary structure of single stranded RNAs

Eliahu Comay1, Ruth Nussinov2,* and Oded Comay3

1Physics Department, School of Mathematics 2Computer Science Department, School of Mathematics 3Computer Center, Tel Aviv University Ramat Aviv, Tel Aviv, Israel

*To whom all correspondence should be addressed

Received July 29, 1983. We describe a code designed for secondary structure computation of single stranded RNA molecules. While it incorporates the same principles as the original algorithm of Nussinov et al (1978), its restructuring improves the logic and the approach of the codes based on it. For long sequences the code is at least an order of magnitude faster. For a chain n nucleotides long, references to computer disk memory are reduced from n3 to less than n2. For n»100, disk references behave like n3/6000.


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