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Nucleic Acids Research, 1984, Vol. 12, No. 1Part2 665-673
© 1984

MICROCOMPUTERS

Interactive computer programs for the graphic analysis of nucleotide sequence data

Verne A. Luckow1,3,*,, Roland K. Littlewood2 and Robert H. Rownd3

1laboratory of Molecular Biology, University of Wisconsin Madison, WI 53706 2Biophysics Laboratory, University of Wisconsin Madison, WI 53706 3Department of Molecular Biology, The Medical and Dental Schools, Northwestern University Chicago, IL 60611, USA

Correspondence concerning these programs should be directed to v. luckow

Received August 30, 1983.

A group of interactive computer programs have been developed which aid in the collection and graphical analysis of nucleotide and protein sequence data. The programs perform the following basic functions: a) enter, edit, list, and rearrange sequence data; b) permit automatic entry of nucleotide sequence data directly from an autoradiograph into the computer; c) search for restriction sites or other specified patterns and plot a linear or circular restriction map, or print their locations; d) plot base composition; e) analyze homology between sequences by plotting a two-dimensional graphic matrix; and f) aid in plotting predicted secondary structures of RNA molecules.

* Present address: Department of Molecular Biology, The Medical and Dental Schools, Northwestern University, Chicago, IL 60611, USA


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