Skip Navigation

This Article
Right arrow Print PDF (2539K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (66)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Wilks, A.
Right arrow Articles by Jost, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilks, A.
Right arrow Articles by Jost, J.-P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1984, Vol. 12, No. 2 1163-1177
© 1984

MOLECULAR BIOLOGY

An estrogen-dependent demethylation at the 5' end of the chicken vitellogenin gene is independent of DNA synthesis

Andrew Wilks40, Monique Seldran and Jean-Pierre Jost41

Friedrich Miescher-lnstitut P.O. Box 2543, CH-4002 Basel, Switzerland

41Friedrich Miescher-Institut, P.O.Box 2543, CH-4002 Basel, Switzerland. To whom reprint requests should be addressed

Received August 23, 1983. Revised November 4, 1983. Accepted November 28, 1983.

A HpaII site 611 base pairs upstream from the 5' end of the chicken vitellogenin II gene exhibits an estrogen-dependent demethylation in hormone-responsive cells. The complete demethylation of this site occurs considerably later than the transcriptional activation of the gene, and therefore appears to be an effect rather than a cause of this activation. In vivo studies using two inhibitors of DNA synthesis (cytosine arabinoside and hydroxyurea) demonstrate that activation of transcription of the gene is independent of DNA synthesis. Surprisingly, the estrogen-dependent demethylation of the HpaII site is also independent of DNA synthesis. The possible involvement of a site-specific demethylase is discussed.

40Present address: Ludwig Institute for Cancer Research, P.O. Royal Melbourne Hospital, Victoria 3050, Australia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
M. J. Lucey, D. Chen, J. Lopez-Garcia, S. M. Hart, F. Phoenix, R. Al-Jehani, J. P. Alao, R. White, K. B. Kindle, R. Losson, et al.
T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
Nucleic Acids Res., November 10, 2005; 33(19): 6393 - 6404.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Detich, V. Bovenzi, and M. Szyf
Valproate Induces Replication-independent Active DNA Demethylation
J. Biol. Chem., July 18, 2003; 278(30): 27586 - 27592.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Cui and N. V. Fedoroff
Inducible DNA Demethylation Mediated by the Maize Suppressor-mutator Transposon-Encoded TnpA Protein
PLANT CELL, November 1, 2002; 14(11): 2883 - 2899.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. R Dimitrova, K. DeGroot, A. K Myers, and Y. D Kim
Estrogen and homocysteine
Cardiovasc Res, February 15, 2002; 53(3): 577 - 588.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.