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Nucleic Acids Research, 1984, Vol. 12, No. 2 1193-1200
© 1984

MOLECULAR BIOLOGY

Transcription in vivo of an Alu family member upstream from the human {varepsilon}-globin gene

Maggi Allan and John Paul

Beatson Institute for Cancer Research, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, UK

Received November 11, 1983. Accepted December 9, 1983.

The more distal Alu repeat flanking the {varepsilon}-globin gene is transcribed in K562 cells to generate transcripts 350–400 nucleotides in length. Initiation occurs at the start of the repeat, upstream of a putative PolIII control signal. These transcripts originate from the strand which does not code (-globin and are oriented in the opposite direction from the gene. They are non-polyadenylated, nucleus-confined and are only detectable in association with expression of the {varepsilon}-globin gene.


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T.-H. Li, C. Kim, C. M. Rubin, and C. W. Schmid
K562 cells implicate increased chromatin accessibility in Alu transcriptional activation
Nucleic Acids Res., August 15, 2000; 28(16): 3031 - 3039.
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