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Nucleic Acids Research, 1984, Vol. 12, No. 20 7787-7792
© 1984

Articles

Reversion to neurovirulence of the live-attenuated Sabin type 3 oral pollovirus vaccine

A.J. Cann, G. Stanway, P.J. Hughes, P.D. Minor*, D.M.A. Evans*, G.C. Schild* and J.W. Almond

Department of Microbiology, Medical Sciences Building, University of Leicester University Road, Leicester LE3 7RH *National Institute for Biological Standards and Control Holly Hill, Hampstead, London NW3 6RB, UK

Received August 29, 1984. Revised October 2, 1984. Accepted October 2, 1984.

The complete nucleotide sequence has been determined of a strain of poliovirus type 3, P3/119, isolated from the central nervous system of a victim of fatal vaccine-associated poliomyelitis. Comparison of this sequence with those obtained previously for the Sabin type 3 vaccine, P3/Leon 12a1 b and its neurovirulent progenitor, P3/Leon/37, reveals that these three strains are on a direct geneaological lineage and therefore that P3/119 is a bona fide revertant of the vaccine. P3/119 differs in sequence from its attenuated vaccine parent at just seven positions. Only one of these differences, a mutation from U to C at position 472 in the presumed noncoding region of the genome, is a back mutation to the wild type sequence. Of the six other differences, three give rise to coding changes in virus structural proteins, two are silent changes in the major open reading frame of the genome and one affects the 3'-terminus just prior to the poly A tract. These differences indicate that there are three possible types of molecular change which could, singly or collectively, result in attenuation and reversion to neurovirulence of the Sabin type 3 vaccine.


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